Product Name | Letrozole |
Alias | Femara |
CAS | 112809-51-5 |
Purity | 99% |
Packing | foil bag or tin. |
Appearance | White or light yellow crystal |
Standard | Enterprise Standard |
Storage | Shading , confined preservation |
Usage | Anti-estrogen |
Molecular Fomular | C17H11N5 |
Molecular Weight | 285.31 |
Molecular Structure |
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Letrozole is approved by the United States Food and Drug Administration (FDA) for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women.
Letrozole has been used for ovarian stimulation by fertility doctors since 2001 because it has fewer side-effects than clomiphene (Clomid) and less chance of multiple gestation.
he risk of birth defects. A more detailed ovulation induction follow-up study found that letrozole, compared with a control group of clomiphene, had significantly lower congenital malformations and chromosomal abnormalities at an overall rate of 2.4% (1.2% major malformations) compared with clomiphene 4.8% (3.0% major malformations). Despite this, India banned the usage of letrozole in 2011, citing potential risks to infants.
Letrozole has been used for ovarian stimulation by fertility doctors since 2001 because it has fewer side-effects than clomiphene (Clomid) and less chance of multiple gestation. A Canadian study presented at the American Society of Reproductive Medicine 2005 Conference suggested that letrozole may increase the risk of birth defects.[citation needed] A more detailed ovulation induction follow-up study found that letrozole, compared with a control group of clomiphene, had significantly lower congenital malformations and chromosomal abnormalities at an overall rate of 2.4% (1.2% major malformations) compared with clomiphene 4.8% (3.0% major malformations). Despite this, India banned the usage of letrozole in 2011, citing potential risks to infants.In 2012, an Indian parliamentary committee said that the drug controller office colluded with letrozole's makers to approve the drug for infertility in India and also stated that letrozole's use for infertility was illegal worldwide; however, such off-label uses are legal in many countries such as the US and UK.
Femara is a powerful Aromatase Inhibitor that was developed to fight breast cancer. For athletes and bodybuilders, it is a drug used to combat the estrogenic side effects of anabolic steroids water-retention, acne and gynocomastia. It will also raise testosterone levels because of the lowered estrogen in the body. Side effects from include a lowered sex drive and continuous use can lead to lowered lipid function and an impaired immune system.
Letrozole is an aromatase inhibitor. It works by reducing the total amount of estrogen produced primarily in the body. This helps to starve cancer cells by depriving them of estrogen.
Letrozole as an anti-estrogen is extremely beneficial to breast cancer patients. Many forms of breast cancer actively feed off the estrogen hormone. By inhibiting the production of estrogen, which in turn lowers the amount of circulating estrogen in the body, this has the ability to starve the cancer. For years Nolvadex was the preferred form of treatment for this purpose. Nolvadex actively binds to the estrogen receptor, thereby preventing estrogen from binding. However, it does not inhibit or lower production. Nolvadex is still extremely valuable in breast cancer treatment plans, but many physicians, especially in extreme cases have begun to use AI’s first. Once the cancer is in remission, at this stage a SERM like Nolvadex may replace the AI in an effort to protect against the cancer reappearing.
Undeniably, AI’s like Letrozole are the most effect means at combating estrogenic related side effects. However, they can also have a negative impact on cholesterol. Alone AI’s do not appear to have a strong, negative effect on cholesterol, but when coupled with an aromatizing steroid like testosterone the adverse cholesterol effect is enhanced. For this reason, many will find SERM’s like Tamoxifen Citrate (Nolvadex) should be their first choice in estrogen protection. SERM’s will not negatively affect cholesterol; in fact, SERM’s, while anti-estrogenic, actively act as estrogens in the liver, and in turn, promote healthier cholesterol levels. We’ll look at this in more detail in the side effect section, and while Letrozole can be used without an adverse cholesterol effect, it will take some effort on your part.
Letrozole is used treat early breast cancer in women who have experienced menopause and who have had other treatments, such as radiation or surgery to remove the tumor. It is also used to treat early breast cancer in women who have experienced menopause and who have already been treated with a medication called tamoxifen (Nolvadex) for 5 years.
Letrozole is also used in women who have experienced menopause as a first treatment of breast cancer that has spread within the breast or to other areas of the body or in women whose breast cancer has worsened while they were taking tamoxifen.
Tests | Specifications | Results |
Appearance | White or off-white crystaline powder | White |
Crystalline powder | ||
Solubility | Soluble in Chloroform; | Conform |
Soluble in ethanol when heated | ||
ldentification | (1)Maximum absorption in wavelength of 240 nm | Conform |
Minimum absorption in wavelength of 215 nm | Conform | |
(2)Infrared spectrum should be in accordance the dominant peak of contrast | In accordance with the dominant peak of contrast | |
Melting points | 182℃-184℃ | 182℃ |
Related substances | ≤0.5% | 0.30% |
Single impurity | ≤0.3% | 0.20% |
Loss on drying | ≤1.0% | 0.80% |
[Assay]C17H11N5 | ≥98.0% | 99.20% |
(On anhydrous basis) | ||
Conclusion | Conforms Specifications of Enterprise Standard. |
Our Advantages / The 7 reasons are as below: |
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1 |
Rich experience |
Our company is a professional leading supplier in pharmaceutical and chemical area for many years. |
2 |
Suitable packagings |
The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also taken in consideration |
3 |
High quality |
High quality guaranteed, product is tested before shipment. |
4 |
Secure shipping |
Shipping by professional forwarder Security EMS/DHL/TNT/FedEx/UPS,AusPost, |
Royal Mail express,etc.Door to door service. |
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5 |
Fast delivery |
We have stock, so we can deliver quickly once payment isreceived. |
6 |
Quality service |
Warm aftersale service is supplied,if any question we |
will reply you within 8 hours. |
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7 |
Competitive prices |
A discount would be given when you make a large order. VIP price for next orders. |
ID | Item | Capacity |
1 | Clenbuterol | 40mcg*100/bottle |
2 | Clomid(Clomiphene) | 50mg*100/bottle |
3 | Letrozle(Femara) | 2.5mg*100/bottle |
4 | Halotestin(Fluoxymesterone) | 10mg*100/bottle |
5 | Dianabol(Methandrostenolone) | 10mg*100/bottle |
6 | Dianabol(Methandrostenolone) | 20mg*100/bottle |
7 | Dianabol(Methandrostenolone) | 50mg*100/bottle |
8 | Proviron(Mesterolone) | 10mg*100/bottle |
9 | Proviron(Mesterolone) | 25mg*100/bottle |
10 | Primobolan(Methenolone Acetate) | 10mg*100/bottle |
11 | Primobolan(Methenolone Acetate) | 25mg*100/bottle |
12 | Primobolan(Methenolone Acetate) | 50mg*100/bottle |
13 | Superdrol(Methasterone) | 10mg*100/bottle |
14 | T3(Liothytonine Sodium) | 25mcg*100/bottle |
15 | T3(Liothytonine Sodium) | 40mcg*100/bottle |
16 | T4 | 40mcg*100/bottle |
17 | Anavar(Oxandrolone) | 10mg*100/bottle |
18 | Anavar(Oxandrolone) | 25mg*100/bottle |
19 | Anavar(Oxandrolone) | 50mg*100/bottle |
20 | Anadrol(Oxymetholone) | 50mg*100/bottle |
21 | Winstrol(Stanozolol) | 10mg*100/bottle |
22 | Winstrol(Stanozolol) | 20mg*100/bottle |
23 | Winstrol(Stanozolol) | 50mg*100/bottle |
24 | Turinabol(Chlordehydromethyltestosterone) | 10mg*100/bottle |
25 | Turinabol(Chlordehydromethyltestosterone) | 25mg*100/bottle |
26 | Nolvadex(Tamoxifen) | 10mg*100/bottle |
27 | Nolvadex(Tamoxifen) | 20mg*100/bottle |
28 | Aromasin(Exemestane) | 25mg*100/bottle |
29 | Arimidex(Anastrozole) | 1mg*100/bottle |
30 | Viagra(Sildenafil) | 100mg*100/bottle |
31 | Cialis(Tadanafil) | 20mg*100/bottle |
Q1: Have your Product Quality been Approved by the Third Party Lab?
A: Yes, all the products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.
Q2: How do you treat quality complaint?
A: First of all, our QC department will do the strict examination of our export products by HPLC, UV, GC ,
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem, caused by us, we will send you free goods for replacement or refund your loss.
Q3: Do you Accept Sample Order?
A: Yes, we can accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.
Q4: Is there any discount?
A: Yes, for the larger quantity, we always support with better price for our further cooperation.
Q5: Do you accept VISA business credit card?
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Q6: How long does it take the goods to arrive?
It is Depending on your location,
For the small order, please expect the 5-7 days by DHL,UPS,TNT, FEDEX, EMS and so on.
For the mass order, please allow the 5-8 days by Air or 20-35 days by Sea.
Q7: Do you have any reshipment policy?
Of course, we have the good after-sale service and re-shipment policy if the parcel lose.
Our long association with our clients has brought great benefits, we always take the upmost care in the packaging of our products. Our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts, it is still possible will seize a small number of packages. In this circumstance we promise reship free to establish a long term relationship with each other.
Q8: Can I get a sample?
A: Of course. For most products, we can provide you a free sample to test the quality, while the shipping cost should be undertook by your side.
We have formed a technology and management team that cooperate closely with some overseas Labs all speak highly of our safe shipping and goods.
please do not hesitate to contact us.